Certainly! Here's a simple game that incorporates elements from Naruto, Hunter x Hunter, Bleach, and One Piece, all in a single HTML file with JavaScript:
In this game, players such as Naruto, Gon from Hunter x Hunter, Ichigo from Bleach, and Monkey D. Luffy from One Piece are represented by objects with properties like health, attack, and defense. The game loop updates the players' health by performing random attacks between them, and displays their information on the canvas. The game loop continues until one of the players' health drops to 0, triggering a "Game Over" alert.
Note that this is a very basic demonstration and can be enhanced further depending on your requirements and game design.