Sure, I can help you create a simple game using JavaScript enclosed in script tags within a single HTML file. Here's an example of a simple "Color or Die" game using pictograms:
Color or Die
In this game, you see four color boxes represented by pictograms (green leaf, blue droplet, yellow sun, and red heart). The game asks you to click on the boxes with colors that are not red. If you click on a red heart, the game is over, and the message "Game Over" is displayed.
You can save the above code in an HTML file (e.g., `color_or_die.html`) and open it in a web browser to play the game. Click on the color boxes to change their background color and try to avoid the red heart!
Note: This is a simple example, and you can modify and expand the game according to your specific requirements.