As an AI text-based model, I can provide you with an example of a simplified game written in HTML and JavaScript inspired by The Binding of Isaac. However, please note that creating a complete game with complex gameplay and pictograms would require extensive development time and resources. Please find a basic interactive game implementation below:
The Binding of Isaac - Simple Game
This code sets up a game scene with a player (red square) and an enemy (blue square). The player can be moved left or right using the arrow keys to avoid colliding with the enemy. If the player collides with the enemy, the game ends, and the player's score is displayed. Please note that this is a very basic example and can be expanded upon to create a more complete game.