Sure, I can provide you with a basic structure for the game. Here's an example of a simple game where you can build and destroy buildings, along with a PvP (Player vs Player) functionality. Since this needs to be implemented as a single HTML file, I'll include the HTML, CSS, and JavaScript code within the script tags.
Please note that this code is a simplified version to demonstrate the concept, and it can be expanded upon with additional features, graphics, and optimizations.
To play the game, you can copy the above code and save it as a .html file. Then, you can open it in a web browser to interact with the game. The game allows the player to move around using arrow keys (left, right, up, down) and create buildings by clicking on the game area. Additionally, buildings can be destroyed by long pressing or holding the mouse click over a building.
Please note that this is just a basic example, and you can further enhance the game by adding scoring, multiplayer functionality, different types of buildings, and more complex interaction mechanics.