Sure! Here's an example of a simple tower defense game implemented as a single HTML file using JavaScript. To keep it simple, I'll use simple text-based representation instead of pictograms, but you can modify it to use pictograms if you prefer.
Please note that this is just a basic structure to get you started with the game. You'll need to implement the game logic, enemy movement, tower placement, shooting, level progression, and other features to complete the game.