Sure, I can help you create a simple pixel art game using JavaScript enclosed in a single HTML file. Here's an example of how you could implement it:
Pixel Art Game
In this game, the HTML file creates a pixel art canvas where you can click on the pixels to change their colors. The canvas is made up of div elements with the class 'pixel'. You can select colors from the color palette at the bottom of the canvas.
You can save this code as a .html file and open it in a web browser to play the finished game.