Sure! Here's an example of a simple Tower Defense game implemented as a single HTML file using JavaScript and enclosed in script tags. Please note that this is a very basic implementation to give you an idea, and you can add more features to enhance the gameplay.
In this implementation, you can click on the game canvas to place towers on the grid cells. Each tower costs $100, and your initial money is $250. The game draws the grid, including towers (represented by a placeholder comment), and the current money and score on the canvas.
Note: The commented out `gameLoop` function is where you can update the game's logic and perform any animations or enemy movements. Uncomment it and add your game logic inside the function if you want to implement a continuous game loop.