Sure! Here's a simple example of a marble run fighting game implemented as a single HTML file with JavaScript. Please note that due to the limited scope of this task, this example game will be quite basic:
In this example, the marble (representing the player) is animating back and forth within the game container. The player's aim is to click on the marble while it's in the red color phase. Clicking on it triggers a victory alert.
Please note that this is a very simplistic implementation and can be expanded further to include more gameplay features, scoring, enemies, levels, etc. I hope this example gives you a starting point for your marble run fighting game.